Targeting the RAS oncogene
نویسندگان
چکیده
منابع مشابه
The molecular perspective: the ras oncogene.
together when to divide, when to differentiate, and when to die. Often, cells communicate with one another by delivering protein messages. These proteins—hormones, growth factors, chemokines, etc.—are far too large to enter the receiving cell, so an elaborate mechanism of signal transduction has been developed, to transmit messages from the cell surface into the cell nucleus, where the topic of...
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Medullary thyroid carcinoma (MTC) is a rare malignancy originating from the calcitonin-secreting parafollicular thyroid C cells. Approximately 75% of cases are sporadic. Rearranged during transfection (RET) proto-oncogene plays a crucial role in MTC development. Besides RET, other oncogenes commonly involved in the pathogenesis of human cancers have also been investigated in MTC. The family of ...
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The frequency of ras (H-, K-, and N-ras) and c-myc oncogenes was investigated in multiple myeloma (MM). By means of the polymerase chain reaction (PCR)/oligonucleotide hybridization method, DNA from 56 tumor biopsies was analyzed for the presence of activating mutations involving codons 12 and 61 of the H-, K-, and N-ras genes and codon 13 of the N-ras gene. Mutations, involving the N- or K-ras...
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Although N-nitroso compounds (NNC) are ubiquitous in the human environment and are known neurocarcinogens in animal models, results of epidemiological studies have not yet convincingly associated NNCs with brain tumor occurrence in humans. Animal studies have suggested that specific codons (12, 13, and 61) in the ras family are mutable by exposure to NNCs. The purpose of this study was to measu...
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pathways control all phases of tumor development and are critical in cancer therapy as they are largely responsible for the ability of tumor cells to survive or die in response to chemotherapy and radiotherapy. The p38 MAPK signaling pathway is one of the routes that cells use extensively to interpret extracellular signals and orchestrate appropriate responses. This pathway was originally chara...
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ژورنال
عنوان ژورنال: Expert Opinion on Therapeutic Targets
سال: 2013
ISSN: 1472-8222,1744-7631
DOI: 10.1517/14728222.2013.764990